DETAILED TABLE OF CONTENTS

• Introduction
• Nivalin is the result of natural product
  • Physico-chemical properties
  • Mechanism of action
  • Pharmacodinamics
    • Anticholinesterase activity
    • Effect of Nivalin on neuromuscular transmission
    • Nivalin as antagonist on non-depolarizing neuromuscular blocking drugs
    • Nivalin and depolarizing neuromuscular blockers
    • Effects of Nivalin on gastrointestinal smooth muscle
    • Effects of Nivalin on urinary bladder and ureter muscles
    • Nivalin and neurotransmission in the upper segment of cervical sympathetic ganglia
    • Nivalin and its effects on the carotid sinus
• Nivalin and the adrenals
  • Effect of Nivalin on the adrenal medulla
  • Effect of Nivalin on adrenal cortex
  • Nivalin and electrophysiology of afferent nerve activity
  • Nivalin and the cardiovascular system
  • Nivalin and the central nervous system
  • Effect of Nivalin on the spinal cord and medulla oblongata
  • Effect of Nivalin on the brain
  • Nivalin and its effects on phagocytosis
    
• Pharmacokinetics
• Safety. Toxicity studies
  • Primary toxic effect and acute toxicity of Nivalin
  • Chronic toxicity of Nivalin
• Mutagenicity of Nivalin
  • Test for mutagenic activity of Nivalin on Salmonella typhimurium strains (AMES test)
  • Tests for mutagenic activity of Nivalin on DNA synthesis in peripheral human lymphocytes
  • Embryotoxicity and teratogenicity of Nivalin
• Clinical application of Nivalin
  • Nivalin in practical anesthesiology as antagonists of nondepolarizing muscle relaxants
  • The optimal decurarization dose of Nivalin is 0.3 mg/kg
  • Nivalin in postoperative atonic ileus and urinary retention
  • Nivalin in the treatment of diseases of the central and peripheral nervous system
  • Nivalin in cerebral diseases
  • Nivalin in spinal cord diseases
  • Nivalin in disease of the peripheral nervous system
  • Nivalin and its application by electrophoresis
  • Nivalin in the treatment of eye diseases
  • Nivalin in diseases associated with impaired neuromuscular transmission
  • Nivalin treatment in functional sexual disorders in men
  • Nivalin as an antidote
  • Nivalin in the treatment of enuresis in children
  • Indications for use of Nivalin
  • Contraindications for use of Nivalin
  • Drug interactions of Nivalin
  • Dosage and route of administration of Nivalin
  • Adverse effects
  • Precautions
  • Dosage form
  • Storage
• References